MIND RESearch projects

MARIJUANA INVESTIGATIONS FOR NEUROSCIENTIFIC DISCOVERY

Observational study of Medical Cannabis Treatment

This study is a non-invasive investigation of participants who currently hold a certification for medical marijuana for various medical and/or psychological conditions. Subjects are assessed at baseline, prior to beginning their medical marijuana treatment regimen and complete clinical and diagnostic scales/interviews, cognitive testing, measures related to quality of life, sleep, general activities, and where appropriate, a neuroimaging session which assesses brain structure, function, chemistry and white matter integrity. Following their visit, subjects track their use of medical cannabis (MC) products daily (type, mode of use, amount, frequency) using a log system, and are in touch with researchers biweekly. Follow up visits occur at 3 months, 6 months, 12 months, 15 months, 18 months, and 24 months post MC treatment initiation in order to better assess the potential impact of MC on cognitive function and related brain and quality of life measures.

Status: currently enrolling research participants 

Open-Label to Double-Blind Placebo-Controlled Randomized Clinical Trial of Cannabidiol (CBD) for Anxiety

The second phase of the MIND program is an FDA-approved clinical trial of a whole plant-derived, high-CBD sublingual tincture for the treatment of anxiety. Subjects are assessed at baseline and weekly for four weeks of treatment. The primary outcome measures of the study are clinical state measures related to anxiety. Additionally, subjects will complete measures related to quality of life, sleep, and activity levels, cognitive testing, and for those who are eligible, neuroimaging to assess brain structure, function, and neurochemistry. Please visit https://clinicaltrials.gov/show/NCT02548559 for more information.

Status: currently enrolling participants 

Medical Cannabis for Veterans

The third study examines clinical state and cognition in multiple cohorts of veterans who are using cannabinoids to treat a variety of conditions, including post-traumatic stress disorder (PTSD), insomnia, and pain, or who are naive to cannabis. Veterans are assessed monthly throughout six months of cannabinoid use, and complete measures of clinical state, quality of life, sleep, and pain, and also complete cognitive testing. A subset of veterans will also participate in MRI to examine brain structure, function, and chemistry during six to twelve months of cannabinoid use.

Status: currently enrolling participants

Longitudinal Study of Chronic Pain in Older Adults

More than half of older adults report bothersome pain within the past month. Further, opioid use for pain is highest among older adults, yet many complain of inadequate relief, significant side effects and increased risk of opioid-related consequences. Medical cannabis (MC) use is increasingly common among older adults for pain relief; however, the potential benefits, risks, and negative consequences of MC in this population have not been assessed, raising serious public health concerns addressed in this proposal. We recently launched a study to examine the impact of MC use on pain and opioid use in older adults. As with the larger, observational study, all patients are assessed before initiating MC treatment, and complete measures of pain, clinical state, quality of life, sleep, brain structure and function. Use of conventional medications, including opioids, are also closely tracked over the course of treatment.

Status: enrolling participants

Investigational New Drug (IND) Approvals

MIND has received FDA approval for a number of INDs:

  • Whole plant-derived high CBD product for anxiety

  • Full spectrum high CBD product for pain

  • Hemp-based, high CBD product for anxiety

  • Whole plant-derived high CBD product for dementia-related anxiety and agitation

Additional IND applications are pending!

ADDITIONAL & FUTURE PROJECTS

Massachusetts Baseline Assessment of Medical Marijuana Patients (BAMMP)

Additional projects for the next phase of MIND are focused on:

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Contact

McLean Hospital

115 Mill St

Belmont, MA 02448

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To volunteer for research​

Call: 617-855-3653

Email: brainstudy@mclean.harvard.edu

TO VOLUNTEER FOR RESEARCH

Call: 617-855-3653
Email: brainstudy@mclean.harvard.edu

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