CCNC projects

Over the years, the CCNC has conducted numerous projects, several of which are highlighted below

funded projects:

--Frontal Neural Mechanisms and Risk for Substance Abuse. This project examined frontal neural circuitry during cognitive tasks in marijuana smokers and controls using neuroimaging techniques; data from this investigation helped inform future marijuana-related research projects in the CCNC.

--Marijuana and Mood: Frontal Predictors of Behavior. This project was designed to examine the relationship between marijuana use and mood changes relative to fMRI measures and white matter structure in chronic marijuana smokers and bipolar patients who used or did not use marijuana.  

--Marijuana: Neurobiologic Correlates of Age of Onset. The goal of this project is to assess chronic, heavy marijuana use with early onset (prior to age 16) vs late onset (after age 16) of marijuana use relative to non-marijuana smoking subjects and former heavy marijuana smokers; this study utilizes a variety of methodologies, including multimodal neuroimaging techniques, cognitive assessments, and clinical ratings.

--Using Novel Technologies to Uncover the Neurophysiology of Bipolar Disorder. This project helped clarify the neurophysiology of bipolar disorder using novel, multimodal imaging techniques

--Novel Approaches for DTI/fMRI Analysis. The goal of this project was to assess the relationship between white matter integrity and neuronal function in bipolar disorder using functional magnetic resonance imaging (fMRI) and multiple diffusion tensor imaging (DTI) techniques.

--Depression Related Glial Changes in Children and Adolescents​. The goal of the study was to examine presumed markers of glial cell metabolism in children and adolescents with depression.

--Made from Concentrate? This online survey examined the use of concentrates, highly potent cannabis products, across the US.

--Marijuana & Driving. Using a custom-designed driving simulator and STISIM software, the goal of this project is to examine the residual effects of recreational and medical cannabis use on driving.

CCNC collaborations

Through collaborations, the CCNC has also been involved in a number of projects dealing with a wide variety of populations and topics, including substance use, bipolar disorder and pediatric bipolar disorder, borderline personality disorder, non-suicidal self injury (NSSI), first episode psychosis, and major depressive disorder. In addition, the CCNC is currently part of several multi-site collaborations:

IDEAA:

Conceptualized by Dr. Gruber and collaborator, Dr. Krista Lisdahl, Imaging Data in Emerging Adults with Addiction (IDEAA) is a multi-site consortium which combines common, overlapping neuroimaging and behavioral measures in MJ-using subjects and healthy controls across a broad and overlapping age range (16-25) for multiple NIH/NIDA-funded sites across the country.  Neuroimaging (structural, resting state fMRI, and diffusion tensor imaging), neurocognitive, clinical, and drug-use data from over 600 participants will be collected at multiple sites across the U.S. and will be pooled in order to create the largest sample of well-characterized emerging adult marijuana users and matched controls to date.

ABCD:
Dr. Gruber serves as a consultant for the national Adolescent Brain Cognitive Development (ABCD) study, a longitudinal investigation of brain development and child health. https://www.addictionresearch.nih.gov/abcd-stud

additional CCNC COLLABORATIONS:

  • A Neuroimaging Study of Reward Processing in Non-Suicidal Self-Injury (Dr. Jill Hooley)
  • Citicoline-Induced Modulation of Cannabis Effects: Imaging and Mechanism of Action (Dr. Scott Lukas)
  • Juvenile Bipolar Disorder and Substance Use:  A Magnetic Resonance Imaging Study (Dr. Tim WIlens)
  • Nabilone for Cannabis Dependence: Imaging and Neuropsychological Performance (Dr. Kevin Hill)
  • Magnetic Resonance Spectroscopy and Metabolite Relaxometry in Major Depression (Dr. David Olson)
  • Pre-Adolescent Siblings of Children with Pediatric Bipolar Disorder: An fMRI Pilot Study (Dr. Janet Wozniak)
  • Early Onset Cigarette Smoking Effects on Brain Structure, Function and Chemistry (Dr. Yasmin Mashhoon)
  • Probing Cerebral Energy Metabolism in Bipolar Disorder Using Functional Magnetic Resonance Spectroscopy (Drs. Dost Ongür & Bruce Cohen)
  • Detecting Risk by Testing Attentional Bias Towards Suicide-Related Words in Patients Being Admitted to an Inpatient Psychiatric Unit (Dr. Beth Murphy)
  • Impact of Nutrient Fortified Foods on Cognitive Functioning Among Food Insecure Children (Dr. Juliana Cohen)
  • Neurobiology of Traumatic Dissociation in a Transdiagnostic Study of Women with Childhood Maltreatment (Dr. Milissa Kaufman)
  • A System for the Specification of Acute THC Impairment using Validated Algorithms (SATIVA) (Drs. Bethany Bracken & Scott Lukas)
  • Efficacy of a Cognitive Remediation Treatment Program for Bipolar Disorder (Dr. K. Eve Lewandowski)
  • Brain Neurochemical Profile During Marijuana Abstinence (Dr. Chun Zuo)

To see a list of our specific collaborators, please visit our Collaborators page.

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Email: brainstudy@mclean.harvard.edu

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Email: brainstudy@mclean.harvard.edu

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